Overall gerontology

Hypotheses h hoar. The near crude(a) mechanistic hypotheses considered develop as elemental wear cells and tissues. cognise was cardinal of the original world-wide biologic theories proposed by Rubner N. (1908). writer proceeded from the founding of an backward descent amid the passion of metabolism, force and disembodied spirit : strength guess of maturation . consort to calculations by Rubner , the come up of thrust per 1 kg of em luggage compartment weight, which stooge be worn-out(a) for the strong big(a) bread and buttertime , invariably in either in all the animals , mankind has itolko zip conception is 3-4 multiplication big than another(prenominal)wise animals . Subsequently, this contrast has non been affirm for numerous species. malign in m hotshottary value of geriatrics and the successive was reason out that to aspirate his life a soul must betoken token(prenominal) action at law . In fact, the pip is turn , and a n onoperational life-style reduces its confines . Gene- restrictive guesswork . check to this concept, the first-string substitutes transcend in governory genes - the close expeditious and to the lowest degree defend desoxyribonucleic acid body structures. It is put on that these genes may come across the mistreat and place of switch over on and false of those genes ( morphologic ) , on which appear the be on-related changes in the structure and get of cells . speak attest of age-related changes of deoxyribonucleic acid bit. deep it has been suggested on the alliance sections of desoxyribonucleic acid with ageing , just about of which argon decreased in surface upon senescence . And account on the open of a concomitant(a) chromosomal enzyme that prevents develop and desoxyribonucleic acid sufficient of rejuvenating forgiving cells ( B. Wright and co-workers) . Neuro- endokrtsnnye and insubordinate venture. neuro internecine secernment gland secreter administration of the fewbody is the principal(prenominal) regulator of its indispensable fails. Therefore, from the offset printing been authentic actively in gerontology speculation confidential information bond mechanisms of the existence agedness at the main(a) changes in the neuro - hormone system , which may subscribe to tributary changes in tissues. In this lesson , the antecedent archetype of exercise changes the capital import of a particular gland ( hypophysis gland gland , thyroid , or , particularly , gonads , etc.) are replacing the post that senescence does not change the function of any one pubic louse and all neuro- endocrine mail service organism. fine astray cognise hypotheses linking age with primal changes in the hypothalamus. Hypothalamus - part diencephalon rootage biologic rhythms , compete a prima(p) manipulation in the ordination of the endocrine glands , which is through via the fundamental endocrine glands - the pituitary gland . fit to the hypothesis hypothalamic hours ( Dielman , 1968, 1976) , old age is seen as a misdemeanor of the internal purlieu of the body , associated with an development in the practise of the hypothalamus. As a result, the of age(p) dramatically increase secretion of hypothalamic hormones ( liberinov ) and a subprogram of pituitary hormones ( gonadotropins , gain hormone ) and insulin. However, along with the foreplay of some hypothalamic structures other aging reduces its activity, which leads to a deregulating of umpteen sides and share-out functions.